GHK-CU

GHK-Cu Overview

GHK-Cu (glycyl-l-histidyl-l-lysine-copper) — commonly known as Copper Tripeptide — is a naturally occurring human peptide found in plasma, saliva, and urine. It binds to copper ions and promotes tissue regeneration, skin rejuvenation, and hair growth, while offering potent anti-inflammatory and anti-aging benefits.

It was originally identified for its role in liver cell regeneration, but subsequent research has revealed its restorative effects across the body — including skin, connective tissue, bone, lungs, nerves, and the digestive system.

Key Benefits

Skin & Anti-Aging

• Stimulates collagen and elastin production for firmer, hydrated skin

• Reverses fine lines, wrinkles, and photoaging

• Improves skin elasticity and tone

• Protects against UV damage and oxidative stress

Cellular & Systemic Regeneration

• Accelerates wound healing and injury recovery

• Promotes angiogenesis (formation of new blood vessels)

• Enhances nerve regeneration and DNA repair

• Reduces inflammation and oxidative stress
  
  

Hair Growth

• Stimulates follicle enlargement and regrowth

• Increases hair thickness and density

• Comparable or superior to Minoxidil 5%
  
  

Internal & Protective Effects

• Improves digestive health and may support liver repair

• Shows anti-cancer properties in preliminary studies

• Reduces pain, anxiety, and aggression

Possible Side Effects

• Topical:
  No major side effects reported.

• Subcutaneous (Injectable):
  Localized redness, swelling, itching, or bruising at injection site.
  Some may experience mild to moderate histamine flare-ups (hive-like reaction or small knot under skin lasting 1–3 days).

Note: This reaction is not universal. Some users experience no pain or irritation, while others are highly sensitive to copper ions.

Signs of Copper Toxicity

• (Usually only with excessive or unsafe copper exposure)
  Headache, nausea, vomiting, diarrhea, black stool, jaundice, or brown ring in eyes.
  Emotional changes such as anxiety or irritability may also appear.
  Severe toxicity can affect liver, kidney, or heart function.

Reconstitution & Dosing (Injectable)

Reconstitution:

Due to the limited volume capacity of the 3 mL vial, directly mixing the 100 mg GHK-Cu powder may result in a highly concentrated solution. To achieve a lower concentration and help minimize potential stinging or discomfort during application, it is recommended to reconstitute the vial with 10 mL of bacteriostatic water.

• Add 3 mL (300 units) of bacteriostatic water to the GHK-CU 100 mg vial.

• Gently swirl the vial in small circles until all powder is fully dissolved. 

• After the GHK-CU powder has completely dissolved, withdraw the entire 3 mL reconstituted solution using a sterile syringe.

• Transfer this 3 mL solution into the remaining 7 mL of bacteriostatic water (into the same 10 mL vial)

• Gently swirl or invert the bottle several times to ensure uniform mixing.

Cycle: 4–6 weeks ON → 4–6 weeks  OFF
 

Administration: Subcutaneous injection (abdomen, thigh, or upper arm)

• 10–20 units (1–2mg) subcutaneously once daily.

• Rotate injection sites to prevent irritation.

Topical Administration

1. Remove vial cap and stopper carefully.

2. Add 0.5–1mL of BAC water until a thick, sludge-like mixture forms.

3. Mix with 15mL to 30mL of your skincare base (cream or serum).

4. Apply evenly to clean skin 1–2x daily.

5. For better absorption, apply under a thick moisturizer.
   
   

Compatible Ingredients:
Hyaluronic acid, Vitamin E, Niacinamide, Ceramides, Collagen, Elastin, Matrixyl 3000, CoQ10, Squalane, Bakuchiol

Avoid Mixing With:
Retinoids, AHAs, BHAs, Glycolic Acid, Salicylic Acid, Vitamin C (L-ascorbic acid)

Injection Sensitivity

If injection causes pain or redness:

• Rotate injection sites each time

• Add 30–90 units of sterile water to dilute

• Try GHK-Cu + BPC-157 blend for reduced irritation

Contraindications & Cautions

Do not use GHK-Cu if you have or are experiencing any of the following:

• Allergies or hypersensitivity. Known allergy to copper, GHK-Cu peptide, or bacteriostatic water components (such as benzyl alcohol).

• Open wounds or active skin infections. Avoid injecting or applying on broken, inflamed, or infected skin to prevent irritation or infection spread.

• Pregnancy and breastfeeding. Safety in pregnant or nursing women has not been established — use is not recommended.

• Severe liver or kidney disease. GHK-Cu is processed through these organs; consult your physician before use.

• Cancer or tumor history. GHK-Cu may stimulate growth factors in tissue repair — avoid if you have active or recent cancer unless approved by a doctor.

• Autoimmune or chronic inflammatory conditions. Use only under medical supervision if you have autoimmune disorders (e.g., lupus, rheumatoid arthritis).

• Metal sensitivity or copper metabolism disorders. Contraindicated in patients with Wilson’s disease or hemochromatosis (conditions affecting metal balance)

Recommended Stacks

• Thymosin Beta-4 / TB-500 – For powerful wound repair and tissue regeneration

• Epithalon – Anti-aging, telomere repair, and DNA protection

• NAD+ – Boosts energy metabolism and anti-aging effects

• Snap-8 or Argireline – For enhanced wrinkle reduction and topical synergy

• Glutathione – For antioxidant replenishment and skin brightening

• CJC-1295 + Ipamorelin – For collagen boost, GH elevation, and systemic anti-aging synergy

• BPC-157 – For gut healing and inflammatory suppression

Caveat / Disclaimer

• This guide is for educational purposes only and does not replace medical advice.

• Peptides in compounded form are not approved by the FDA or the Philippine DOH for safety, quality, or effectiveness.

• All medications carry risks. Side effects, allergic reactions, or complications may occur.

• Only a licensed healthcare professional can decide if these peptides are safe for you.

• Do not use if you have medical condition or without medical supervision.

• By using these products, you accept that it is provided “as is”, with no guarantee of results, safety, or effectiveness.

• LUMI+ PEPTIDES PH is not responsible for any misuse, side effects, or complications.